Microsoft's OneDrive cloud storage service is installed on your PC by default, and it can cause some trouble when playing PC games on multiple devices.
After about 30 minutes of troubleshooting and a reinstall, I finally chased down the settings file for the game — and sure enough, it was applying a settings file that had been synced to OneDrive, overwriting my settings changes each time I tried to apply them.
Any service that defaults to overwriting newer files can burn in hell.
Any service that defaults to overwriting newer files can burn in hell.