Retail is a person favorite, though I dont know how popular it is.

Something Positive is a comic I’ve followed for close to two decades. It’s a slice of Life comic that follows a misanthrope named Davan and his (mis)adventures with a lot of dry and relatively poignant humor.

Shade the changing girl is kind of an out there comic. I’m also a big fan of Tomboy. American virgin is neat, same with The molting.

Arsenic Lullaby is one of my all-time favorites.

There’s a man who was cursed by a witch doctor and has to get revenge to appease the magic or whatever, but he ran out of people to get revenge on so now he gets revenge on behalf of other people.

There’s a couple of census agents whose job it is to maintain the accuracy of the census by making sure the birth rate matches the death rate.

I won’t spoil any more, but it’s all very sick and hilarious.

I highly recommend The Perry Bible Fellowship

Back at the turn of the millennium I remember enjoying 1/0 by Tailsteak. I’m glad to see that it’s still available.

I’m a big fan of Saturday Morning Breakfast Cereal, a webcomic.

Not lesser known but my favorite: Gary Larson’s The far side always gave me a chuckle.

I think you’re going to have to dig into the wayback machine (because I don’t think they’re actively hosted anywhere anymore?), but Nothing Nice To Say by Mitch Clem was a great punk rock web comic from the 2000s.

Well, if you’re looking for unrelatable and occasionally disgusting comics, check out mine. 😎

Poorly Drawn Lines.

I loved “The adventures of Oscar Zahn” great read. Alternatively if you have never read Garfield there is a bot who posts all the strip in chronological order over at Garfield@lemmy.world

Also before “The odd ones out” made his weird and abstract comics, he did actually make a funny little series similar to the peanuts

Falseknees makes gorgeous comics about birds. Each strip feels like art

Work chronicles makes funny corporate related strips but has inconsistent posting

Rustledjimmies made some great comics in the past but I haven’t heard of him in a long time

Newspaper style comics specifically? Maybe Fraz. Revolves around a janitor working at an elementary school. I haven’t kept up with it but the creator cites Calvin and Hobbes as an inspiration and I love what I’ve read so far.